Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease.
beta-Amyloid formation requires multiple abnormal proteolytic cleavages of amyloid precursor protein (APP), including one within its intramembrane domain. Lysosomes, which contain a wide variety of proteases (cathepsins) and other acid hydrolases, are major sites for the turnover of membrane protein...
محفوظ في:
| الحاوية / القاعدة: | Proc Natl Acad Sci U S A |
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| المؤلفون الرئيسيون: | , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
National Academy of Sciences
1991
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1837142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.24.10998 |
| الوسوم: |
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