Differential inhibitory action of apixaban on platelet and fibrin components of forming thrombi: Studies with circulating blood and in a platelet-based model of thrombin generation

INTRODUCTION: Mechanisms of action of direct oral anticoagulants (DOAC) suggest a potential therapeutic use in the prevention of thrombotic complications in arterial territories. However, effects of DOACs on platelet activation and aggregation have not been explored in detail. We have investigated t...

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Publicat a:PLoS One
Autors principals: Pujadas-Mestres, Lluis, Lopez-Vilchez, Irene, Arellano-Rodrigo, Eduardo, Reverter, Joan Carles, Lopez-Farre, Antonio, Diaz-Ricart, Maribel, Badimon, Juan Jose, Escolar, Gines
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5305231/
https://ncbi.nlm.nih.gov/pubmed/28192448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171486
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