Differential inhibitory action of apixaban on platelet and fibrin components of forming thrombi: Studies with circulating blood and in a platelet-based model of thrombin generation

INTRODUCTION: Mechanisms of action of direct oral anticoagulants (DOAC) suggest a potential therapeutic use in the prevention of thrombotic complications in arterial territories. However, effects of DOACs on platelet activation and aggregation have not been explored in detail. We have investigated t...

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Udgivet i:PLoS One
Main Authors: Pujadas-Mestres, Lluis, Lopez-Vilchez, Irene, Arellano-Rodrigo, Eduardo, Reverter, Joan Carles, Lopez-Farre, Antonio, Diaz-Ricart, Maribel, Badimon, Juan Jose, Escolar, Gines
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5305231/
https://ncbi.nlm.nih.gov/pubmed/28192448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171486
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