Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene.

The PRNP gene, encoding the amyloid precursor protein that is centrally involved in Creutzfeldt-Jakob disease (CJD), has an unstable region of five variant tandem octapeptide coding repeats between codons 51 and 91. We screened a total of 535 individuals for the presence of extra repeats in this reg...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Goldfarb, L G, Brown, P, McCombie, W R, Goldgaber, D, Swergold, G D, Wills, P R, Cervenakova, L, Baron, H, Gibbs, C J, Gajdusek, D C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53045/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1683708/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.23.10926
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