Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability

Myotonic dystrophy type 1 (DM1) is an autosomal-dominant multi-system disease caused by expanded CTG repeats in dystrophia myotonica protein kinase (DMPK). The expanded CTG repeats are unstable and can increase the length of the gene with age, which worsens the symptoms. In order to establish a huma...

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Pubblicato in:Sci Rep
Autori principali: Ueki, Junko, Nakamori, Masayuki, Nakamura, Masahiro, Nishikawa, Misato, Yoshida, Yoshinori, Tanaka, Azusa, Morizane, Asuka, Kamon, Masayoshi, Araki, Toshiyuki, Takahashi, Masanori P., Watanabe, Akira, Inagaki, Nobuya, Sakurai, Hidetoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304155/
https://ncbi.nlm.nih.gov/pubmed/28211918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42522
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