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Novel Implications in Molecular Diagnosis of Lynch Syndrome

About 10% of total colorectal cancers are associated with known Mendelian inheritance, as Familial Adenomatous Polyposis (FAP) and Lynch syndrome (LS). In these cancer types the clinical manifestations of disease are due to mutations in high-risk alleles, with a penetrance at least of 70%. The LS is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Gastroenterol Res Pract
Hauptverfasser: Liccardo, Raffaella, De Rosa, Marina, Izzo, Paola, Duraturo, Francesca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303590/
https://ncbi.nlm.nih.gov/pubmed/28250766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/2595098
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