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Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
BACKGROUND: Retinoid therapy is widely employed in clinical oncology to differentiate malignant cells into their more benign counterparts. However, certain high-risk cohorts, such as patients with MYCN-amplified neuroblastoma, are innately resistant to retinoid therapy. Therefore, we employed a prec...
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| Publicado en: | Genome Med |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5303304/ https://ncbi.nlm.nih.gov/pubmed/28187790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-017-0407-3 |
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