TP53 hot spot mutations in ovarian cancer: Selective resistance to microtubule stabilizers in vitro and differential survival outcomes from The Cancer Genome Atlas

OBJECTIVE: To test if TP53 hot spot mutations (HSMs) confer differential chemotherapy resistance or survival outcomes, the effects of microtubule stabilizers on human ovarian carcinoma cells (OCCs) expressing TP53 HSMs were studied in vitro. Survival outcomes of patients with high grade serous epith...

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Publicat a:Gynecol Oncol
Autors principals: Seagle, Brandon-Luke L., Yang, Chia-Ping Huang, Eng, Kevin H., Dandapani, Monica, Odunsi-Akanji, Oluwatosin, Goldberg, Gary L., Odunsi, Kunle, Horwitz, Susan Band, Shahabi, Shohreh
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303002/
https://ncbi.nlm.nih.gov/pubmed/25958320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2015.04.039
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