uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy

There is strong evidence supporting the role of the plasminogen activator system in head and neck squamous cell carcinoma (HNSCC), particularly of its uPA (urokinase plasminogen activator) / uPAR (urokinase plasminogen activator receptor) and SERPINE1 components. Overexpression of uPA/uPAR and SERPI...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Pavón, Miguel Angel, Arroyo-Solera, Irene, Céspedes, Maria Virtudes, Casanova, Isolda, León, Xavier, Mangues, Ramón
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302994/
https://ncbi.nlm.nih.gov/pubmed/27385000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10344
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