Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8(+) T Cells

Peripheral tolerance is an important mechanism by which the immune system can guarantee a second line of defense against autoreactive T and B cells. One autoimmune disease that is related to a break of peripheral tolerance is diabetes mellitus type 1. Using the RIP-GP mouse model, we analyzed the ro...

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Publicat a:Front Immunol
Autors principals: Honke, Nadine, Shaabani, Namir, Teijaro, John R., Christen, Urs, Hardt, Cornelia, Bezgovsek, Judith, Lang, Philipp A., Lang, Karl S.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5301005/
https://ncbi.nlm.nih.gov/pubmed/28239381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00113
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