Orthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates

A strategy for the preparation of homogeneous antibody–drug conjugates (ADCs) containing multiple payloads has been developed. This approach utilizes sequential unmasking of cysteine residues with orthogonal protection to enable site‐specific conjugation of each drug. In addition, because the approa...

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Udgivet i:Angew Chem Int Ed Engl
Main Authors: Levengood, Matthew R., Zhang, Xinqun, Hunter, Joshua H., Emmerton, Kim K., Miyamoto, Jamie B., Lewis, Timothy S., Senter, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299463/
https://ncbi.nlm.nih.gov/pubmed/27966822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201608292
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