ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib()

The ataxia telangiectasia mutated (ATM) protein kinase plays a central role in the cellular response to DNA damage. Loss or inactivation of both copies of the ATM gene (ATM) leads to ataxia telangiectasia, a devastating childhood condition characterized by neurodegeneration, immune deficiencies, and...

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Bibliographic Details
Published in:Transl Oncol
Main Authors: Wang, Chen, Jette, Nicholas, Moussienko, Daniel, Bebb, D. Gwyn, Lees-Miller, Susan P.
Format: Artigo
Language:Inglês
Published: Neoplasia Press 2017
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Original article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299208/
https://ncbi.nlm.nih.gov/pubmed/28182994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2017.01.007
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