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Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale

Resistance against all available antimalarial drugs calls for novel compounds that hit unexploited targets in the parasite. Here, we show that the recently discovered Plasmodium falciparum lactate/proton symporter, PfFNT, is a valid druggable target, and describe a new class of fluoroalkyl vinylogou...

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Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Golldack, André, Henke, Björn, Bergmann, Bärbel, Wiechert, Marie, Erler, Holger, Blancke Soares, Alexandra, Spielmann, Tobias, Beitz, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5298233/
https://ncbi.nlm.nih.gov/pubmed/28178358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006172
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