Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

Mutant mitochondrial DNA with large-scale deletions (delta-mtDNA) has been frequently observed in patients with chronic progressive external ophthalmoplegia (CPEO), a subgroup of the mitochondrial encephalomyopathies. To exclude involvement of the nuclear genome in expression of the mitochondrial dy...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Hayashi, J, Ohta, S, Kikuchi, A, Takemitsu, M, Goto, Y, Nonaka, I
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52980/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1720544/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.23.10614
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