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Optimizing assembly and production of native bispecific antibodies by codon de-optimization
When production of bispecific antibodies requires the co-expression and assembly of three or four polypeptide chains, low expression of one chain can significantly limit assembly and yield. κλ bodies, fully human bispecific antibodies with native IgG structure, are composed of a common heavy chain a...
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| Опубликовано в: : | MAbs |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5297534/ https://ncbi.nlm.nih.gov/pubmed/28001485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1267088 |
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