Impact of SPR biosensor assay configuration on antibody: Neonatal Fc receptor binding data

Binding interactions with the neonatal Fc receptor (FcRn) are one determinant of pharmacokinetic properties of recombinant human monoclonal antibody (rhumAb) therapeutics, and a conserved binding motif in the crystallizable fragment (Fc) region of IgG molecules interacts with FcRn. Surface plasmon r...

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Publicado en:MAbs
Autores principales: Wang, Xiangdan, McKay, Patrick, Yee, Liliana T., Dutina, George, Hass, Philip E., Nijem, Ihsan, Allison, David, Cowan, Kyra J., Lin, Kevin, Quarmby, Valerie, Yang, Jihong
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
Materias:
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297514/
https://ncbi.nlm.nih.gov/pubmed/28001487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1261774
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