Marine Streptomyces sp. derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependent ubiquitin–proteasome system

Four new antimycin alkaloids (1–4) and six related known analogs (5–10) were isolated from the culture of a marine derived Streptomyces sp. THS-55, and their structures were elucidated by extensive spectroscopic analysis. All of the compounds exhibited potent cytotoxicity in vitro against HPV-transf...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Zhang, Weiyi, Che, Qian, Tan, Hongsheng, Qi, Xin, Li, Jing, Li, Dehai, Gu, Qianqun, Zhu, Tianjiao, Liu, Ming
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296914/
https://ncbi.nlm.nih.gov/pubmed/28176847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42180
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items