Marine Streptomyces sp. derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependent ubiquitin–proteasome system

Four new antimycin alkaloids (1–4) and six related known analogs (5–10) were isolated from the culture of a marine derived Streptomyces sp. THS-55, and their structures were elucidated by extensive spectroscopic analysis. All of the compounds exhibited potent cytotoxicity in vitro against HPV-transf...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Zhang, Weiyi, Che, Qian, Tan, Hongsheng, Qi, Xin, Li, Jing, Li, Dehai, Gu, Qianqun, Zhu, Tianjiao, Liu, Ming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296914/
https://ncbi.nlm.nih.gov/pubmed/28176847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42180
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