Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

Organ interactions resulting from drug, metabolite or xenobiotic transport between organs are key components of human metabolism that impact therapeutic action and toxic side effects. Preclinical animal testing often fails to predict adverse outcomes arising from sequential, multi-organ metabolism o...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vernetti, Lawrence, Gough, Albert, Baetz, Nicholas, Blutt, Sarah, Broughman, James R., Brown, Jacquelyn A., Foulke-Abel, Jennifer, Hasan, Nesrin, In, Julie, Kelly, Edward, Kovbasnjuk, Olga, Repper, Jonathan, Senutovitch, Nina, Stabb, Janet, Yeung, Catherine, Zachos, Nick C., Donowitz, Mark, Estes, Mary, Himmelfarb, Jonathan, Truskey, George, Wikswo, John P., Taylor, D. Lansing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296733/
https://ncbi.nlm.nih.gov/pubmed/28176881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42296
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