Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells

The existence of cancer stem cells (CSCs) in non-small cell lung cancer (NSCLC) has profound implications for cancer therapy. In this study, a disulfiram/copper (DSF/Cu) complex was evaluated in vitro and in vivo for its efficacy to inhibit CSCs, which drive recurrence of NSCLC. First, we investigat...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Liu, Xinwei, Wang, Lihui, Cui, Wei, Yuan, Xiangzhong, Lin, Lulu, Cao, Qi, Wang, Nannan, Li, Yi, Guo, Wei, Zhang, Xun, Wu, Chunfu, Yang, Jingyu
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295448/
https://ncbi.nlm.nih.gov/pubmed/27542268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11305
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