The T160A hemagglutinin substitution affects not only receptor binding property but also transmissibility of H5N1 clade 2.3.4 avian influenza virus in guinea pigs

We generated and characterized site-directed HA mutants on the genetic backbone of H5N1 clade 2.3.4 virus preferentially binding to α-2,3 receptors in order to identify the key determinants in hemagglutinin rendering the dual affinity to both α-2,3 (avian-type) and α-2,6 (human-type) linked sialic a...

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Detalhes bibliográficos
Publicado no:Vet Res
Main Authors: Gu, Min, Li, Qunhui, Gao, Ruyi, He, Dongchang, Xu, Yunpeng, Xu, Haixu, Xu, Lijun, Wang, Xiaoquan, Hu, Jiao, Liu, Xiaowen, Hu, Shunlin, Peng, Daxin, Jiao, Xinan, Liu, Xiufan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294818/
https://ncbi.nlm.nih.gov/pubmed/28166830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13567-017-0410-0
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