Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer

BACKGROUND: Numerous DNA-damaging cellular stresses, including oncogene activation and DNA-damage response (DDR), may lead to cellular senescence. Previous observations linked microRNA deregulation with altered senescent patterns, prompting us to investigate whether epigenetic repression of microRNA...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Ramalho-Carvalho, João, Graça, Inês, Gomez, Antonio, Oliveira, Jorge, Henrique, Rui, Esteller, Manel, Jerónimo, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294724/
https://ncbi.nlm.nih.gov/pubmed/28166834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-017-0415-1
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