Impact of CTLA-4 blockade in conjunction with metronomic chemotherapy on preclinical breast cancer growth

BACKGROUND: Although there are reports that metronomic cyclophosphamide (CTX) can be immune stimulating, the impact of its combination with anti-CTLA-4 immunotherapy for the treatment of cancer remains to be evaluated. METHODS: Murine EMT-6/P breast cancer, or its cisplatin or CTX-resistant variants...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Br J Cancer
Autori principali: Parra, Karla, Valenzuela, Paloma, Lerma, Natzidielly, Gallegos, Alejandra, Reza, Luis C, Rodriguez, Georgialina, Emmenegger, Urban, Di Desidero, Teresa, Bocci, Guido, Felder, Mitchell S, Manciu, Marian, Kirken, Robert A, Francia, Giulio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294484/
https://ncbi.nlm.nih.gov/pubmed/28056464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.429
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