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Conserved GTPase LepA (Elongation Factor 4) functions in biogenesis of the 30S subunit of the 70S ribosome

The physiological role of LepA, a paralog of EF-G found in all bacteria, has been a mystery for decades. Here, we show that LepA functions in ribosome biogenesis. In cells lacking LepA, immature 30S particles accumulate. Four proteins are specifically underrepresented in these particles—S3, S10, S14...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Gibbs, Michelle R., Moon, Kyung-Mee, Chen, Menglin, Balakrishnan, Rohan, Foster, Leonard J., Fredrick, Kurt
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293072/
https://ncbi.nlm.nih.gov/pubmed/28096346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613665114
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