Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging

The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: de Bourcy, Charles F. A., Angel, Cesar J. Lopez, Vollmers, Christopher, Dekker, Cornelia L., Davis, Mark M., Quake, Stephen R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293037/
https://ncbi.nlm.nih.gov/pubmed/28096374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617959114
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