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Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging
The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5293037/ https://ncbi.nlm.nih.gov/pubmed/28096374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617959114 |
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