Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging

The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: de Bourcy, Charles F. A., Angel, Cesar J. Lopez, Vollmers, Christopher, Dekker, Cornelia L., Davis, Mark M., Quake, Stephen R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293037/
https://ncbi.nlm.nih.gov/pubmed/28096374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617959114
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki