Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging

The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: de Bourcy, Charles F. A., Angel, Cesar J. Lopez, Vollmers, Christopher, Dekker, Cornelia L., Davis, Mark M., Quake, Stephen R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293037/
https://ncbi.nlm.nih.gov/pubmed/28096374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617959114
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