Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging

The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: de Bourcy, Charles F. A., Angel, Cesar J. Lopez, Vollmers, Christopher, Dekker, Cornelia L., Davis, Mark M., Quake, Stephen R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293037/
https://ncbi.nlm.nih.gov/pubmed/28096374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617959114
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