A Model of Induction of Cerebellar Long-Term Depression Including RKIP Inactivation of Raf and MEK

We report an updated stochastic model of cerebellar Long Term Depression (LTD) with improved realism. Firstly, we verify experimentally that dissociation of Raf kinase inhibitor protein (RKIP) from Mitogen-activated protein kinase kinase (MEK) is required for cerebellar LTD and add this interaction...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Hepburn, Iain, Jain, Anant, Gangal, Himanshu, Yamamoto, Yukio, Tanaka-Yamamoto, Keiko, De Schutter, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292618/
https://ncbi.nlm.nih.gov/pubmed/28220061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00019
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