Blocking the CCL2-CCR2 axis using CCL2 neutralizing antibody is an effective therapy for hepatocellular cancer in a mouse model

Hepatocellular carcinoma (HCC), a deadly disease, commonly arises in the setting of chronic inflammation. C-C motif chemokine ligand2 (CCL2/MCP1), a chemokine that recruits CCR2-positive immune cells to promote inflammation, is highly upregulated in HCC patients. Here, we examined the therapeutic ef...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Teng, Kun-Yu, Han, Jianfeng, Zhang, Xiaoli, Hsu, Shu-hao, He, Shun, Wani, Nissar, Barajas, Juan, Snyder, Linda A., Frankel, Wendy L., Caligiuri, Michael A., Jacob, Samson T., Yu, Jianhua, Ghoshal, Kalpana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292068/
https://ncbi.nlm.nih.gov/pubmed/27980102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0124
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