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A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target gene expression

SCOPE: Histone deacetylases (HDACs) have emerged as epigenetic regulators of risk factors associated with the metabolic syndrome (MetS), and certain botanical extracts have proven to be potent HDAC inhibitors. Understanding the role of dietary procyanidins in HDAC inhibition is important in explorin...

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Detalhes bibliográficos
Publicado no:Mol Nutr Food Res
Main Authors: Downing, Laura E., Ferguson, Bradley S., Rodriguez, Kelvin, Ricketts, Marie-Louise
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292052/
https://ncbi.nlm.nih.gov/pubmed/27624175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201600347
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