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A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target gene expression

SCOPE: Histone deacetylases (HDACs) have emerged as epigenetic regulators of risk factors associated with the metabolic syndrome (MetS), and certain botanical extracts have proven to be potent HDAC inhibitors. Understanding the role of dietary procyanidins in HDAC inhibition is important in explorin...

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Библиографические подробности
Опубликовано в: :Mol Nutr Food Res
Главные авторы: Downing, Laura E., Ferguson, Bradley S., Rodriguez, Kelvin, Ricketts, Marie-Louise
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292052/
https://ncbi.nlm.nih.gov/pubmed/27624175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201600347
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