Chalcomycin Biosynthesis Gene Cluster from Streptomyces bikiniensis: Novel Features of an Unusual Ketolide Produced through Expression of the chm Polyketide Synthase in Streptomyces fradiae

Chalcomycin, a 16-membered macrolide antibiotic made by the bacterium Streptomyces bikiniensis, contains a 2,3-trans double bond and the neutral sugar d-chalcose in place of the amino sugar mycaminose found in most other 16-membered macrolides. Degenerate polyketide synthase (PKS)-specific primers w...

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Main Authors: Ward, Shannon L., Hu, Zhihao, Schirmer, Andreas, Reid, Ralph, Revill, W. Peter, Reeves, Christopher D., Petrakovsky, Oleg V., Dong, Steven D., Katz, Leonard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Chemistry; Biosynthesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC529187/
https://ncbi.nlm.nih.gov/pubmed/15561847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4703-4712.2004
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