Bifunctional Conjugates with Potent Inhibitory Activity Towards Cyclooxygenase and Histone Deacetylase

We herein disclose a series of compounds with potent inhibitory activities towards histone deacetylases (HDAC) and cyclooxygenases (COX). These compounds potently inhibited the growth of cancer cell lines consistent with their anti-COX and anti-HDAC activities. While compound 2b showed comparable le...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Raji, Idris, Yadudu, Fatima, Janeira, Emily, Fathi, Shaghayegh, Szymczak, Lindsey, Kornacki, James Richard, Komatsu, Kensei, Li, Jian-Dong, Mrksich, Milan, Oyelere, Adegboyega K.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291751/
https://ncbi.nlm.nih.gov/pubmed/28057407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.12.032
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