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The Leishmania major LACK Antigen with an Immunodominant Epitope at Amino Acids 156 to 173 Is Not Required for Early Th2 Development in BALB/c Mice

The Leishmania major LACK antigen contains an immunodominant epitope at amino acids 156 to 173 (LACK(156-173)) that is believed to nucleate the pathological Th2 immune response in susceptible BALB/c mice. To test this hypothesis, we generated L. major parasites that express a mutated LACK that fails...

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Autori principali: Kelly, Ben L., Locksley, Richard M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC529165/
https://ncbi.nlm.nih.gov/pubmed/15557613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.12.6924-6931.2004
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