Interactions of Pulmonary Collectins with Bordetella bronchiseptica and Bordetella pertussis Lipopolysaccharide Elucidate the Structural Basis of Their Antimicrobial Activities

Surfactant proteins A (SP-A) and D (SP-D) play an important role in the innate immune defenses of the respiratory tract. SP-A binds to the lipid A region of lipopolysaccharide (LPS), and SP-D binds to the core oligosaccharide region. Both proteins induce aggregation, act as opsonins for neutrophils...

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Detalhes bibliográficos
Main Authors: Schaeffer, Lyndsay M., McCormack, Francis X., Wu, Huixing, Weiss, Alison A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529120/
https://ncbi.nlm.nih.gov/pubmed/15557636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.12.7124-7130.2004
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