Hippocampal activation, memory performance in young and old, and the risk for sporadic Alzheimer’s disease converge genetically to calcium signaling

IMPORTANCE: Human episodic memory performance is linked to the function of specific brain regions, including the hippocampus, declines as a result of increasing age, and is markedly disturbed in Alzheimer’s disease (AD), an age-associated neurodegenerative disorder affecting primarily the hippocampu...

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Veröffentlicht in:JAMA Psychiatry
Hauptverfasser: Heck, Angela, Fastenrath, Matthias, Coynel, David, Auschra, Bianca, Bickel, Horst, Freytag, Virginie, Gschwind, Leo, Hartmann, Francina, Jessen, Frank, Kaduszkiewicz, Hanna, Maier, Wolfgang, Milnik, Annette, Pentzek, Michael, Riedel-Heller, Steffi G., Spalek, Klara, Vogler, Christian, Wagner, Michael, Weyerer, Siegfried, Wolfsgruber, Steffen, de Quervain, Dominique F., Papassotiropoulos, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291164/
https://ncbi.nlm.nih.gov/pubmed/26332608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamapsychiatry.2015.1309
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