Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites

Excessive myocardial collagen deposition and cross-linking (CCL), a process regulated by lysyl oxidase (LOX), determines left ventricular (LV) stiffness and dysfunction. The angiotensin II antagonist losartan, metabolized to the EXP3179 and EXP3174 metabolites, reduces myocardial fibrosis and LV sti...

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發表在:Sci Rep
Main Authors: Miguel-Carrasco, José Luis, Beaumont, Javier, San José, Gorka, Moreno, María U., López, Begoña, González, Arantxa, Zalba, Guillermo, Díez, Javier, Fortuño, Ana, Ravassa, Susana
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291109/
https://ncbi.nlm.nih.gov/pubmed/28157237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41865
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