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Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites
Excessive myocardial collagen deposition and cross-linking (CCL), a process regulated by lysyl oxidase (LOX), determines left ventricular (LV) stiffness and dysfunction. The angiotensin II antagonist losartan, metabolized to the EXP3179 and EXP3174 metabolites, reduces myocardial fibrosis and LV sti...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291109/ https://ncbi.nlm.nih.gov/pubmed/28157237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41865 |
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