Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic inflammation and is known to exacerbate progression of neurodegenerative disease. To gain insights into the links between inflammation, the KP and multiple sclerosis (MS) pathogenesis, we investigated the KP meta...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lim, Chai K., Bilgin, Ayse, Lovejoy, David B., Tan, Vanessa, Bustamante, Sonia, Taylor, Bruce V., Bessede, Alban, Brew, Bruce J., Guillemin, Gilles J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290739/
https://ncbi.nlm.nih.gov/pubmed/28155867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41473
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