KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling

Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway. Activation of this pathway involves Shh-induced ciliary accumulation of Smoot...

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Pubblicato in:Nat Commun
Autori principali: Schou, Kenneth B., Mogensen, Johanne B., Morthorst, Stine K., Nielsen, Brian S., Aleliunaite, Aiste, Serra-Marques, Andrea, Fürstenberg, Nicoline, Saunier, Sophie, Bizet, Albane A., Veland, Iben R., Akhmanova, Anna, Christensen, Søren T., Pedersen, Lotte B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290278/
https://ncbi.nlm.nih.gov/pubmed/28134340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14177
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