Mutant IDH1 expression drives TERT promoter reactivation as part of the cellular transformation process

Mutations in the isocitrate dehydrogenase gene IDH1 are common in lower-grade glioma where they result in the production of 2-hydroxyglutarate (2HG), disrupted patterns of histone methylation and gliomagenesis. IDH1 mutations also co-segregate with mutations in the ATRX gene and the TERT promoter, s...

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Publicado en:Cancer Res
Autores principales: Ohba, Shigeo, Mukherjee, Joydeep, Johannessen, Tor-Christian, Mancini, Andrew, Chow, Tracy T., Wood, Matthew, Jones, Lindsey, Mazor, Tali, Marshall, Roxanne E., Viswanath, Pavithra, Walsh, Kyle M., Perry, Arie, Bell, Robert J. A., Phillips, Joanna J., Costello, Joseph F., Ronen, Sabrina M., Pieper, Russell O.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290072/
https://ncbi.nlm.nih.gov/pubmed/27758882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0696
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