Lower Placental Leptin Promoter Methylation in Association with Fine Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in the ENVIRONAGE Cohort

BACKGROUND: Particulate matter with a diameter ≤ 2.5 μm (PM2.5) affects human fetal development during pregnancy. Oxidative stress is a putative mechanism by which PM2.5 may exert its effects. Leptin (LEP) is an energy-regulating hormone involved in fetal growth and development. OBJECTIVES: We inves...

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Veröffentlicht in:Environ Health Perspect
Hauptverfasser: Saenen, Nelly D., Vrijens, Karen, Janssen, Bram G., Roels, Harry A., Neven, Kristof Y., Vanden Berghe, Wim, Gyselaers, Wilfried, Vanpoucke, Charlotte, Lefebvre, Wouter, De Boever, Patrick, Nawrot, Tim S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Institute of Environmental Health Sciences 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289914/
https://ncbi.nlm.nih.gov/pubmed/27623604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP38
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