Adeno-Associated Virus Serotype 9–Driven Expression of BAG3 Improves Left Ventricular Function in Murine Hearts With Left Ventricular Dysfunction Secondary to a Myocardial Infarction

Mutations in Bcl-2–associated athanogene 3 (BAG3) were associated with skeletal muscle dysfunction and dilated cardiomyopathy. Retro-orbital injection of an adeno-associated virus serotype 9 expressing BAG3 (rAAV9-BAG3) significantly (p < 0.0001) improved left ventricular ejection fraction, fract...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Knezevic, Tijana, Myers, Valerie D., Su, Feifei, Wang, JuFang, Song, Jianliang, Zhang, Xue-Qian, Gao, Erhe, Gao, Guofeng, Madesh, Muniswamy, Gupta, Manish K., Gordon, Jennifer, Weiner, Kristen N., Rabinowitz, Joseph, Ramsey, Frederick V., Tilley, Douglas G., Khalili, Kamel, Cheung, Joseph Y., Feldman, Arthur M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289821/
https://ncbi.nlm.nih.gov/pubmed/28164169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.08.008
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