Uncoupling substrate and activation functions of rotavirus NSP5: Phosphorylation of Ser-67 by casein kinase 1 is essential for hyperphosphorylation

Rotavirus NSP5 is a nonstructural protein that localizes in viroplasms of virus-infected cells. NSP5 interacts with NSP2 and undergoes a complex posttranslational hyperphosphorylation, generating species with reduced PAGE mobility. Here we show that NSP5 operates as an autoregulator of its own phosp...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Eichwald, Catherine, Jacob, Germaine, Muszynski, Bartosz, Allende, Jorge E., Burrone, Oscar R.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2004
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC528968/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15520389/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406691101
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