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Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis

The carcinogen 2-acetylaminofluorene forms two major DNA adducts: N-(2′-deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) and its deacetylated derivative, N-(2′-deoxyguanosin-8-yl)-2-aminofluorene (dG-AF). Although the dG-AAF and dG-AF adducts are distinguished only by the presence or absence of an...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Dutta, Shuchismita, Li, Ying, Johnson, Donald, Dzantiev, Leonid, Richardson, Charles C., Romano, Louis J., Ellenberger, Tom
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC528967/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15528277/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406516101
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