Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma

BACKGROUND: Klotho, is a transmembrane protein, performs as a circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast growth factor (FGF), and Wnt signaling pathways. These pathways are involved in the development and progression of B cell lymphom...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Zhou, Xiangxiang, Fang, Xiaosheng, Jiang, Yujie, Geng, Lingyun, Li, Xinyu, Li, Ying, Lu, Kang, Li, Peipei, Lv, Xiao, Wang, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288890/
https://ncbi.nlm.nih.gov/pubmed/28153033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-017-0391-5
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