Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps

OBJECTIVE: Whereas few adenomas become cancer, most colorectal cancers arise from adenomas. Telomere length is a recognized biomarker in multiple cancers, and telomere maintenance mechanisms (TMM) are exploited by malignant cells. We sought to determine whether telomere length and TMM distinguish ca...

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Veröffentlicht in:Clin Transl Gastroenterol
Hauptverfasser: Druliner, Brooke R, Ruan, Xiaoyang, Johnson, Ruth, Grill, Diane, O'Brien, Daniel, Lai, Tsung-Po, Rashtak, Shahrooz, Felmlee-Devine, Donna, Washechek-Aletto, Jill, Malykh, Andrei, Smyrk, Thomas, Oberg, Ann, Liu, Hongfang, Shay, Jerry W, Ahlquist, David A, Boardman, Lisa A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Contributions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288594/
https://ncbi.nlm.nih.gov/pubmed/27584834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ctg.2016.48
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