DNA Methylation Identifies Loci Distinguishing Hereditary Nonpolyposis Colorectal Cancer Without Germ-Line MLH1/MSH2 Mutation from Sporadic Colorectal Cancer

OBJECTIVES: Roughly half of hereditary nonpolyposis colorectal cancer (HNPCC) cases are Lynch syndrome and exhibit germ-line mutations in DNA mismatch repair (MMR) genes; the other half are familial colorectal cancer (CRC) type X (FCCTX) and are MMR proficient. About 70% of Lynch syndrome tumors hav...

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Detalhes bibliográficos
Publicado no:Clin Transl Gastroenterol
Main Authors: Chen, Chung-Hsing, Sheng Jiang, Shih, Hsieh, Ling-Ling, Tang, Reiping, Hsiung, Chao A, Tsai, Hui-Ju, Chang, I-Shou
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Contributions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288582/
https://ncbi.nlm.nih.gov/pubmed/27977020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ctg.2016.59
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