Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling

Here we study the effects of inducible oncogenic K-Ras (G12V) expression on the polarized morphogenesis of colonic epithelial cells. We provide evidence that the autocrine production of heregulins, ligands for the ErbB3 receptor tyrosine kinase, is responsible for the hyperproliferation and aberrant...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Möller, Yvonne, Morkel, Markus, Schmid, Jens, Beyes, Sven, Hendrick, Janina, Strotbek, Michaela, Riemer, Pamela, Schmid, Simone, Schmitt, Lisa C., Kontermann, Roland, Mürdter, Thomas, Schwab, Matthias, Sers, Christine, Olayioye, Monilola A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288203/
https://ncbi.nlm.nih.gov/pubmed/27447549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10658
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