Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling

Here we study the effects of inducible oncogenic K-Ras (G12V) expression on the polarized morphogenesis of colonic epithelial cells. We provide evidence that the autocrine production of heregulins, ligands for the ErbB3 receptor tyrosine kinase, is responsible for the hyperproliferation and aberrant...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncotarget
Päätekijät: Möller, Yvonne, Morkel, Markus, Schmid, Jens, Beyes, Sven, Hendrick, Janina, Strotbek, Michaela, Riemer, Pamela, Schmid, Simone, Schmitt, Lisa C., Kontermann, Roland, Mürdter, Thomas, Schwab, Matthias, Sers, Christine, Olayioye, Monilola A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2016
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288203/
https://ncbi.nlm.nih.gov/pubmed/27447549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10658
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